I. Mueller

IgM plays a prominent role in naturally acquired immunity against Plasmodium falciparum gametocytes

This study identifies IgM as a key antibody isotype in immune responses against Plasmodium falciparum gametocytes, showing its superior complement fixation activity compared to IgG.

Single-cell RNA profiling of Plasmodium vivax-infected hepatocytes reveals parasite- and host- specific transcriptomic signatures and therapeutic targets

This study uses single-cell RNA sequencing to analyze P. vivax-infected hepatocytes, identifying transcriptomic differences between schizonts and hypnozoites and potential therapeutic targets.

Naturally acquired antibody kinetics against Plasmodium vivax antigens in people from a low malaria transmission region in western Thailand

This study tracks antibody kinetics against Plasmodium vivax antigens in individuals from a low-transmission region, showing long-lived IgG responses and IgM variability.

Emergence of artemisinin-resistant Plasmodium falciparum with kelch13 C580Y mutations on the island of New Guinea

The paper identifies the emergence of artemisinin-resistant Plasmodium falciparum with kelch13 C580Y mutations in Papua New Guinea and suggests an independent origin with distinct genetic features.

Monitoring Plasmodium falciparum and Plasmodium vivax using microsatellite markers indicates limited changes in population structure after substantial transmission decline in Papua New Guinea

The paper uses microsatellite markers to monitor genetic changes in Plasmodium falciparum and Plasmodium vivax populations in Papua New Guinea after malaria control efforts, finding limited population structure changes despite reduced prevalence.

A comparison of non-magnetic and magnetic beads for measuring IgG antibodies against P. vivax antigens in a multiplexed bead-based assay using Luminex(R) technology (Bio-Plex(R)200 or MAGPIX(R))

This study compares non-magnetic and magnetic beads for measuring IgG antibodies against P. vivax antigens using Luminex technology across different instruments, finding strong correlations but noting higher protein requirements for magnetic beads.

Age-independent influence of hematopoietic stem and progenitor cell populations during hematopoietic reconstitution

This study compares the impact of donor age on hematopoietic reconstitution using a murine HSCT model with a multicolor barcode system, showing HSCs and MPPs drive reconstitution regardless of age.

Naturally acquired blocking human monoclonal antibodies to Plasmodium vivax reticulocyte binding protein 2b

The paper isolates and characterizes human monoclonal antibodies against PvRBP2b that block its function in P. vivax invasion.

Transcriptional memory-like imprints and enhanced functional activity in γδ T cells following resolution of malaria infection

This study shows that malaria exposure enhances transcriptional memory-like features and functional activity in γδ T cells, supporting antigen-presentation during subsequent infections.

Improved yield of AAV2 and rAAV2-retro serotypes following sugar supplementation during the viral production phase

This study shows that adding sucrose or sorbitol during AAV production increases yields of AAV2 and rAAV2-retro serotypes by 1.8-fold and 1.5-fold, respectively, without affecting purity or infectivity.

Transcriptome and histone epigenome of Plasmodium vivax salivary-gland sporozoites point to tight regulatory control and potential mechanisms for liver-stage differentiation.

This study characterizes the transcriptome and histone epigenome of Plasmodium vivax sporozoites, revealing transcriptional and post-transcriptional control mechanisms and potential pathways for hypnozoite formation.

Development and validation of serological markers for detecting recent exposure to Plasmodium vivax infection

The paper identifies and validates a panel of 8 P. vivax proteins whose IgG antibody responses can detect recent exposure to P. vivax infections within the prior 9 months with 80% sensitivity and specificity.

Protective immunity against severe malaria is associated with antibodies to a conserved repertoire of PfEMP1 variants

The paper identifies antibody responses to conserved PfEMP1 variants associated with protection against severe malaria, while showing limited association with uncomplicated malaria.

Longitudinal tracking of Plasmodium falciparum clones in complex infections by amplicon deep sequencing

This study compares Amp-Seq and length-polymorphism genotyping for tracking Plasmodium falciparum clones in longitudinal infections, finding Amp-Seq more sensitive for detecting minority clones.

An automated barcode tracking system for behavioural studies in birds

This paper describes an automated barcode tracking system for monitoring bird behavior, demonstrating its reliability, affordability, and ability to capture long-term behavioral data.

Human Migration And The Spread Of Malaria Parasites To The New World

This study uses phylogenetic analysis and gene flow modeling to trace the geographic origins and migration patterns of malaria parasites in the Americas, finding contributions from Africa, South Asia, and Melanesia.

Development Of Amplicon Deep Sequencing Markers And Data Analysis Pipeline For Genotyping Multi-Clonal Malaria Infections

The paper develops amplicon deep sequencing markers and a pipeline for genotyping multi-clonal malaria infections, showing improved sensitivity for detecting minority clones.