mTORC1 induces eukaryotic translation initiation factor 4E interaction with TOS-S6 kinase 1 and its activation
S. T. Majeed, A. Batool, R. Majeed, N. N. Bhat, K. I. Andrabi
The paper shows that phosphorylated eIF4E interacts with the TOS motif of S6K1, relieving its auto-inhibition and enabling activation independent of mTORC1.
bioRxiv · Feb 15, 2020Cell Biology