The macrocyclizing protease butelase 1 remains auto-catalytic and reveals the structural basis for ligase activity
A. M. James, J. Haywood, J. Leroux, K. Ignasiak, A. G. Elliott, J. W. Schmidberger, M. F. Fisher, S. G. Nonis, R. Fenske, C. S. Bond, J. S. Mylne
The paper shows butelase 1 retains cleavage activity despite being classified as a ligase, with structural insights into its macrocyclization efficiency.
bioRxiv · Oct 21, 2018Biophysics