Author

M. F. Fisher

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 7 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Organism:plant (other)· 6 Assay:protein structure· 4 Research Focus:cell type annotation· 3 Research Focus:protein folding & dynamics· 3 Assay:proteomics· 3 Research Focus:protein structure prediction· 2 Organism:Arabidopsis· 1

Frequent Co-Authors

J. S. Mylne· 8 shared K. J. Rosengren· 5 shared C. D. Payne· 4 shared G. Vadlamani· 4 shared C. S. Bond· 3 shared J. Zhang· 3 shared R. J. Clark· 3 shared F. Hajiaghaalipour· 2 shared

Activity by Year

2018-2021 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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8 shared papersBiochemistry

J. S. Mylne

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8 papers

Recent·Most cited

Crystal structure of Arabidopsis thaliana HPPK/DHPS, a bifunctional enzyme and target of the herbicide asulam

G. Vadlamani, K. V. Sukhoverkov, J. Haywood, K. J. Breese, M. F. Fisher, K. A. Stubbs, C. S. Bond, J. S. Mylne

The paper solves the crystal structure of Arabidopsis thaliana HPPK/DHPS, revealing structural conservation with bacterial enzymes and exploring the herbicidal and antibacterial activity of asulam and related compounds.

bioRxiv · Nov 10, 2021Biochemistry

Solution NMR and racemic crystallography provide insights into a novel structural class of cyclic plant peptides

C. D. Payne, G. Vadlamani, F. Hajiaghaalipour, T. Muhammad, M. F. Fisher, H. S. Andersson, U. Göransson, R. J. Clark, C. S. Bond, J. S. Mylne, K. J. Rosengren

The paper uses solution NMR and racemic crystallography to characterize the structure of PDP-23 and related peptides, revealing their unique folding and potential as drug scaffolds.

bioRxiv · Jul 28, 2021Biochemistry

Structural Characterization of the PawL-Derived Peptide Family, an Ancient Subfamily of Orbitides

C. D. Payne, M. F. Fisher, J. S. Mylne, K. J. Rosengren

The paper characterizes the structural features of nine PawL-Derived Peptides (PLPs), revealing beta-turns and sequence diversity but no antibacterial or antifungal activity.

bioRxiv · Jul 18, 2021Biochemistry

A Chameleonic Macrocyclic Peptide with Drug Delivery Applications

C. D. Payne, B. Franke, M. F. Fisher, F. Hajiaghaalipour, C. E. McAleese, A. Song, C. Eliasson, J. Zhang, A. Jayasena, G. Vadlamani, R. J. Clark, R. F. Minchin, J. S. Mylne, K. J. Rosengren

The paper describes a chameleonic macrocyclic peptide, PDP-23, which can adopt different structures and is used to create a cell-penetrating inhibitor of the P-glycoprotein drug efflux pump.

bioRxiv · Dec 16, 2020 · PreprintBiochemistry

The genetic origin of evolidine, the first cyclopeptide discovered in plants, and related orbitides

M. F. Fisher, C. Payne, T. Chetty, D. Crayn, O. Berkowitz, J. Whelan, K. J. Rosengren, J. S. Mylne

The paper rediscovered evolidine, a plant cyclic peptide, and identified its biosynthetic origin through de novo transcriptomics, revealing a diverse family of related peptides in Rutaceae.

bioRxiv · Jun 10, 2020Biochemistry

Defining the familial fold of the vicilin-buried peptide family

C. D. Payne, G. Vadlamani, M. F. Fisher, J. Zhang, R. J. Clark, J. S. Mylne, K. J. Rosengren

The paper characterizes the structural features of Vicilin Buried Peptides (VBPs) using solution NMR spectroscopy, revealing a helix-loop-helix hairpin fold stabilized by disulfide bonds and inter-helix interactions.

bioRxiv · May 26, 2020Biochemistry

Novel cyclic peptides in seed of Annona muricata are ribosomally synthesised

M. F. Fisher, J. Zhang, O. Berkowitz, J. Whelan, J. S. Mylne

The paper identifies ten novel cyclic peptides in Annona muricata seeds and reveals their ribosomal biosynthesis mechanism through transcriptomic and mass spectrometry analysis.

bioRxiv · Feb 16, 2020Biochemistry

The macrocyclizing protease butelase 1 remains auto-catalytic and reveals the structural basis for ligase activity

A. M. James, J. Haywood, J. Leroux, K. Ignasiak, A. G. Elliott, J. W. Schmidberger, M. F. Fisher, S. G. Nonis, R. Fenske, C. S. Bond, J. S. Mylne

The paper shows butelase 1 retains cleavage activity despite being classified as a ligase, with structural insights into its macrocyclization efficiency.

bioRxiv · Oct 21, 2018Biophysics