Early Steps of Protein Disaggregation by Hsp70 Chaperone and Class B J-Domain Proteins are Shaped by Hsp110
W. Sztangierska, H. Wyszkowski, M. Pokornowska, K. Kochanowicz, M. Rychlowski, K. Liberek, A. Klosowska
This study shows Hsp110 NEF enhances Hsp70 disaggregation of protein aggregates, particularly with Class B JDPs, and disrupts JDP-Hsp70 interactions to modulate disaggregation efficiency.
bioRxiv · Oct 31, 2023Biochemistry