A small molecule stabilises the disordered native state of the Alzheimer's Aβ peptide
T. Löhr, K. Kohlhoff, G. T. Heller, C. Camilloni, M. Vendruscolo
This study identifies a small molecule that stabilizes the disordered native state of the Alzheimer's Aβ42 peptide through dynamic binding involving π-stacking and entropic effects.
bioRxiv · Nov 10, 2021 · PreprintBiophysics