G. T. Heller

Micromolar fluoride contamination arising from glass NMR tubes and a simple solution for biomolecular applications

The paper identifies fluoride contamination from glass NMR tubes and proposes a simple solution to mitigate it in biomolecular applications.

Small-molecule binding to an intrinsically disordered protein revealed by experimental NMR 19F transverse spin-relaxation

This study shows that 19F transverse relaxation rates from NMR can detect small-molecule binding to intrinsically disordered proteins, demonstrating 5-fluoroindole binds to HCV NS5A with a Kd of 260 ± 110 M.

A small molecule stabilises the disordered native state of the Alzheimer's Aβ peptide

This study identifies a small molecule that stabilizes the disordered native state of the Alzheimer's Aβ42 peptide through dynamic binding involving π-stacking and entropic effects.

Small molecule sequestration of amyloid-β as a drug discovery strategy for Alzheimer's disease

This paper identifies a small molecule that binds and sequesters monomeric amyloid-β, inhibiting its aggregation and rescuing toxicity in a C. elegans model.

A kinetic ensemble of the Alzheimer's Aβ peptide

This study develops a Markov state model to determine the kinetic ensemble of Aβ42, revealing fast inter-state transitions and predominantly unfolded or short-lived partially-folded states.

Thermodynamic and kinetic design principles for protein aggregation inhibitors

This study develops a kinetic theory to identify thermodynamic and kinetic signatures of effective protein aggregation inhibitors.