Author

K. Mallela

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:proteomics· 4 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Research Focus:protein folding & dynamics· 2 Organism:virus· 1

Frequent Co-Authors

A. Lucas· 4 shared V. Upadhyay· 4 shared C. Patrick· 3 shared S. Panja· 2 shared R. Miyauchi· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

5 top collaborators · 9 mutual co-author links

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4 shared papersBiophysics

A. Lucas

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4 papers

Recent·Most cited

Biophysical evolution of the receptor binding domains of SARS-CoVs

V. Upadhyay, S. Panja, A. Lucas, C. Patrick, K. Mallela

This study compares the biophysical properties of SARS-CoV and SARS-CoV-2 receptor binding domains, finding differences in stability, aggregation, and ACE2 binding affinity.

bioRxiv · Jun 13, 2023Biophysics

Biophysical fitness landscape of the SARS-CoV-2 Delta variant receptor binding domain

C. Patrick, V. Upadhyay, A. Lucas, K. Mallela

This study examines how biophysical properties of the Delta variant's RBD correlate with clinical outcomes, finding that L452R mutation drives immune escape rather than receptor binding.

bioRxiv · Feb 21, 2022Biophysics

Convergent evolution of multiple mutations improves the viral fitness of SARS-CoV-2 variants by balancing positive and negative selection

V. Upadhyay, C. Patrick, A. Lucas, K. Mallela

The paper examines how convergent mutations in SARS-CoV-2 variants balance positive and negative selection to enhance viral fitness.

bioRxiv · Dec 23, 2021Biophysics

Interplay between receptor binding, immune escape and protein stability determines the natural selection of SARS-CoV-2 variants

V. Upadhyay, A. Lucas, S. Panja, R. Miyauchi, K. Mallela

The paper evaluates how mutations in SARS-CoV-2's receptor binding domain affect protein stability, ACE2 binding, and antibody escape, showing multiple factors influence variant selection.

bioRxiv · May 23, 2021Biophysics