K. Mika

Transposable elements continuously remodel the regulatory landscape, transcriptome, and function of decidual stromal cells

This study shows transposable elements (TEs) remodel the transcriptome and regulatory landscape of decidual stromal cells through two waves, with latent enhancer functions unmasked by histone deacetylase inhibitors.

Gene expression phylogenies and ancestral transcriptome reconstruction resolves major transitions in the origins of pregnancy

This study uses ancestral transcriptome reconstruction to trace the evolution of pregnancy in vertebrates, finding that maternal gene expression correlates with placental invasion and suggesting an early origin of hemochorial placentation in eutherians.

Evolutionary transcriptomics implicates new genes and pathways in human pregnancy and adverse pregnancy outcomes

The paper identifies human-specific gene expression changes in the endometrium linked to pregnancy traits and pathologies, suggesting evolutionary insights for understanding adverse pregnancy outcomes.

Bacterial community dynamics during embryonic development of the little skate (Leucoraja erinacea)

This study investigates the bacterial microbiota during the embryonic development of the little skate, identifying site-specific and stage-specific communities and evidence of vertical microbial transmission.

Evolutionary transcriptomics implicates HAND2 in the origins of implantation and regulation of gestation length

This study identifies HAND2 as a key regulator of implantation and gestation length by analyzing its expression and regulatory networks at the maternal-fetal interface in eutherian mammals.

KD-64 - a new selective A2A adenosine receptor antagonist has anti-inflammatory activity but contrary to the non-selective antagonist - caffeine does not reduce diet-induced obesity in mice

KD-64, a selective A2A adenosine receptor antagonist, shows anti-inflammatory effects and improves glucose tolerance in obese mice, unlike caffeine which does not reduce obesity but increases inflammation markers.