Rapid Assessment of T-Cell Receptor Specificity of the Immune Repertoire
X. Lin, J. T. George, N. P. Schafer, K. Ng Chau, M. E. Birnbaum, C. Clementi, J. N. Onuchic, H. Levine
This paper introduces RACER, a pairwise energy model that assesses TCR-peptide affinity using supervised machine learning, demonstrating its utility in simulating thymic selection and estimating recognition rates for tumor antigens.
bioRxiv · Apr 6, 2020Biophysics