Author

N. P. Schafer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Assay:CITE-seq· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1

Frequent Co-Authors

P. G. Wolynes· 2 shared X. Gu· 2 shared A. Motso· 1 shared A. Rising· 1 shared B. M. Hällberg· 1 shared C. Clementi· 1 shared C. Sahin· 1 shared D. Lama· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersBiophysics

P. G. Wolynes

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3 papers

Recent·Most cited

Mass spectrometry of RNA-binding proteins during liquid-liquid phase separation reveals distinct assembly mechanisms and droplet architectures

C. Sahin, A. Motso, X. Gu, H. Feyrer, D. Lama, T. Arndt, A. Rising, G. V. Gese, B. M. Hällberg, E. G. Marklund, N. P. Schafer, K. Petzold, K. Teilum, P. G. Wolynes, M. Landreh

The paper uses mass spectrometry and simulations to study phase separation of RNA-binding proteins, revealing distinct assembly mechanisms and droplet structures.

bioRxiv · Sep 28, 2022Biophysics

Vectorial Channeling as a Mechanism for Translational Control by Functional Prions and Condensates

X. Gu, N. P. Schafer, P. G. Wolynes

The paper shows how mRNA/prion assemblies regulate translation through vectorial channeling, with repression or activation depending on mRNA distribution and assembly structure.

bioRxiv · Aug 19, 2021Biophysics

Rapid Assessment of T-Cell Receptor Specificity of the Immune Repertoire

X. Lin, J. T. George, N. P. Schafer, K. Ng Chau, M. E. Birnbaum, C. Clementi, J. N. Onuchic, H. Levine

This paper introduces RACER, a pairwise energy model that assesses TCR-peptide affinity using supervised machine learning, demonstrating its utility in simulating thymic selection and estimating recognition rates for tumor antigens.

bioRxiv · Apr 6, 2020Biophysics