Gastrointestinal absorption of pimozide is enhanced by inhibition of P-glycoprotein
H. Morishita, K. Okawa, M. Ishii, K. Mizoi, H. Arakawa, K. Yano, T. Ogihara
The paper investigates drug-drug interactions between pimozide, sertraline, and aripiprazole, showing that the latter two inhibit P-glycoprotein, increasing pimozide absorption and potentially causing QT prolongation.
bioRxiv · Apr 16, 2020Pharmacology & Toxicology