TIF1γ drives oral cancer recurrence by the transcriptional regulation of self-renewal genes, such as HES1
K. P. Padmaja, Amrutha Mohan, G Madhumathy Nair, Jyothi S. Prabhu, Hafsa Shabeer, V. P. Snijesh, P.G. Balagopal, A Thameem, Alan Jose, Nebu Abraham George, Jiss Maria Louis, Parvathy Visakh, Gayathri V Nair, Anna P. Joseph, Vishnu Sunil Jaikumar, , Tessy Thomas Maliekal
This study identifies TIF1γ as a driver of oral cancer recurrence by promoting self-renewal through acetylation-dependent regulation of HES1 and other stemness genes.
bioRxiv · Dec 4, 2025 · PreprintCancer Biology