Jyothi S. Prabhu

Endocrine therapy-specific lineage and partial epithelial-mesenchymal reprogramming defines divergent resistant cell-states in ER+ breast cancer

This study identifies drug-specific resistance mechanisms in ER+ breast cancer by analyzing multi-omic data, revealing distinct transcriptional and chromatin states associated with SERM, SERD, and ESR1 mutant resistance.

TIF1γ drives oral cancer recurrence by the transcriptional regulation of self-renewal genes, such as HES1

This study identifies TIF1γ as a driver of oral cancer recurrence by promoting self-renewal through acetylation-dependent regulation of HES1 and other stemness genes.

Repurposing statins in combination therapy for effective ablation of metastatic breast cancer

This study evaluates lovastatin's efficacy in combination with chemotherapy to ablate chemoresistant metastatic breast cancer cells by targeting Macc1 overexpression.

Multi-modal transcriptomic analysis unravels enrichment of hybrid epithelial/mesenchymal state and enhanced phenotypic heterogeneity in basal breast cancer

The paper uses multi-modal transcriptomic data to show basal breast cancer exhibits hybrid epithelial/mesenchymal states and higher phenotypic heterogeneity compared to luminal breast cancer.