First-in-class Transactivator-Free, Doxycycline-inducible IL-18-engineered CAR-T cells for relapsed/refractory B-cell lymphomas
P. L. Justicia-Lirio, M. Tristan-Manzano, N. Maldonado-Perez, C. Barbero-Jimenez, M. Cortijo-Gutierrez, K. Pavlovic, F. J. Molina-Estevez, P. Munoz, A. Hinckley-Boned, C. Grinan-Lison, S. A. Navarro-Marchal, J. Munoz-Ballester, P. A. Gonzalez-Sierra, C. Herrera, J. A. Marchal, F. Martin
This paper develops doxycycline-inducible IL-18 CAR-T cells (iTRUCK19.18) that enhance antitumor activity while controlling IL-18 release through dual mechanisms.
bioRxiv · Jan 23, 2024 · PreprintImmunology