Leveraging a physiologically based quantitative translational modeling platform for designing bispecific T cell engagers for treatment of multiple myeloma
T. Yoneyama, M.-S. Kim, K. Piatkov, H. Wang, A. Z. X. Zhu
This paper develops a computational model to predict immune synapse formation for TCEs in multiple myeloma, showing similar immune synapse numbers between two clinical TCEs at their efficacious doses.
bioRxiv · Dec 6, 2021 · PreprintPharmacology & Toxicology