The concerted action of E2-2 and HEB is critical for early lymphoid specification
T. Bouderlique, L. Pena Perez, S. Kharazi, M. Hils, X. Li, A. Krstic, A. de Paepe, C. Schachtrup, C. Gustafsson, D. Holmberg, K. Schachtrup, R. Mansson
This study shows that E2-2 and HEB are essential for early lymphoid specification, as their disruption blocks B-cell and T-cell development while leaving other hematopoietic lineages unaffected.
bioRxiv · Nov 9, 2018Immunology