R. Mansson

Aging is associated with functional and molecular changes in distinct hematopoietic stem cell subsets

This study shows that aging causes functional and molecular changes in distinct hematopoietic stem cell subsets, including increased myeloid differentiation and age-dependent gene expression changes.

FOXO dictates initiation of B cell development and myeloid restriction in common lymphoid progenitors

The paper shows that FOXO1 and FOXO3 are essential for B cell development and myeloid restriction in common lymphoid progenitors, with their combined loss causing developmental block and loss of B cell lineage.

Cell-intrinsic functions of the transcription factor Bhlhe40 in activated B cells and T follicular helper cells restrain the germinal center reaction and prevent lymphomagenesis

This study shows that Bhlhe40 restrains germinal center reaction in B and T cells, preventing lymphoma by limiting TFH and GC B cell proliferation.

FOXO1 and FOXO3 cooperatively regulate innate lymphoid cell development

This study identifies FOXO1 and FOXO3 as cooperative regulators of innate lymphoid cell development and maturation, affecting lineage specification and response to IL-15.

The concerted action of E2-2 and HEB is critical for early lymphoid specification

This study shows that E2-2 and HEB are essential for early lymphoid specification, as their disruption blocks B-cell and T-cell development while leaving other hematopoietic lineages unaffected.

Mice deficient of Myc super-enhancer region reveal a differential control mechanism between normal and pathological growth

This study shows that deleting the Myc super-enhancer region in mice reduces Myc expression and tumor susceptibility without overt phenotypes, suggesting therapeutic potential for targeting this element in cancer.