Diurnal differences in intracellular replication within splenic macrophages correlates with the outcome of pneumococcal infection.
R. G. Hames, Z. Jasiunaite, G. Ercoli, J. J. Wanford, D. Carreno, K. Straatman, L. Martinez-Pomares, H. Yesilkaya, S. Glenn, E. R. Moxon, P. W. Andrew, C. P. Kyriacou, M. R. Oggioni
This study shows that pneumococcal infection in mice during their active phase leads to faster septicaemia onset and higher bacterial burden in splenic macrophages compared to rest phase infection.
bioRxiv · Jan 30, 2022Microbiology