Deciphering the role of mucosal immune responses and cervicovaginal microbiome in resistance to HIV infection in HIV-exposed seronegative (HESN) women
S. Munusamy Ponnan, K. Thiruvengadam, C. Tellapragada, A. T Ambikan, A. Narayanan, S. Kathirvel, J. Shankar, A. Rajaraman, M. Afsan Amanulla, D. Thongadi Ramesh, P. Selvamuthu, S. Shanmugam, M. Kailapuri Gangatharan, S. Swaminathan, V. Velu, , L. E. Hanna
This study identifies elevated antiviral cytokines, immunoglobulins, and specific immune cell subsets in HESN women, along with increased bacterial diversity and Gardnerella spp abundance in the cervicovaginal microbiome, suggesting protective mechanisms against HIV.
bioRxiv · May 7, 2021Immunology