Phylostratigraphic analysis of tumor and developmental transcriptomes reveals relationship between oncogenesis, phylogenesis and ontogenesis
J. Zhou, L. Cisneros, T. Knijnenburg, K. Trachana, P. Davies, S. Huang
The paper analyzes the evolutionary ages of cancer-related genes and finds they are enriched for pre-Metazoan genes, suggesting cancer reverts to an ancestral state.
bioRxiv · Oct 5, 2017Cancer Biology