S. Huang

Discovery of RNA-Protein Molecular Clamps Using Proteome-Wide Stability Assays

The paper develops a method to discover RNA-protein-small molecule complexes using proteome-wide stability assays and applies it to identify novel DDX helicase targets of rocaglates.

Enhanced Recognition of a Herbal Compound Epiberberine by a DNA Quadruplex-Duplex Structure

This paper investigates how epiberberine binds to a DNA quadruplex structure and shows how modifying the DNA structure enhances binding affinity, leading to a new method for extracting the compound from plant extracts.

Genotypic and phenotypic consequences of domestication in dogs

This study uses runs of homozygosity to link genetic diversity with non-disease phenotypes in dogs, finding associations with traits like height, weight, and fur length.

FLASH Irradiation Regulates IFN-β induction by mtDNA via Cytochrome c Leakage

This study shows FLASH irradiation increases cytochrome c leakage from mitochondria in normal cells, reducing mtDNA accumulation and IFN-β secretion, while having the opposite effect in cancer cells.

Partitioning changes in ecosystem productivity by effects of species interactions in biodiversity experiments

The paper introduces a competitive partitioning model to distinguish effects of species interactions on ecosystem productivity using simulated and experimental data.

Non-invasive optoacoustic imaging visualizes exercise-induced dermal revascularization in obese mice

The paper uses optoacoustic imaging to monitor microvascular changes in obese mice during exercise, showing improved vascular density and oxygenation in adipose tissues.

Deep learning based genomic breeding of pest-resistant grapevine

This study uses deep learning and genome-wide association studies to identify pest-resistant genes in grapevine, achieving high accuracy in predicting pest damage.

Versatile roles of protein flavinylation in bacterial extracyotosolic electron transfer

This study investigates the role of protein flavinylation in bacterial extracytosolic electron transfer by analyzing genomic, structural, and biochemical data.

Development of Broad-spectrum β-cyclodextrins-Based Nanomaterials Against Influenza Viruses

This study develops CD-SA, a β-cyclodextrin-based nanomaterial that acts as a potent broad-spectrum antiviral against influenza A and B viruses, showing higher efficacy than Oseltamivir in ex vivo and in vivo tests.

Role of Hepatocyte RIPK1 in Maintaining Liver Homeostasis during Metabolic Challenges

This study identifies RIPK1 in hepatocytes as critical for maintaining liver homeostasis during metabolic challenges, showing its role in preventing inflammation and apoptosis in mice.

ATG6 interacting with NPR1 increases Arabidopsis thaliana resistance to Pst DC3000/avrRps4 by increasing its nuclear accumulation and stability

This study shows ATG6 interacts with NPR1, enhancing its nuclear accumulation and stability, which boosts Arabidopsis resistance to Pst DC3000/avrRps4.

RNA Splicing Junction Landscape Reveals Abundant Tumor-Specific Transcripts in Human Cancer

This study analyzes RNA splicing junctions in 34,775 samples to identify 29,051 tumor-specific transcripts linked to cancer stemness, poor prognosis, and immunotherapy targets.

Second Boost of Omicron SARS-CoV-2 S1 Subunit Vaccine Induced Broad Humoral Immune Responses in Elderly Mice

This study shows that a second booster dose of an Omicron S1 subunit vaccine enhances broad humoral immunity and cross-neutralizing antibodies in elderly mice.

Biologically Driven In Vivo Occlusion Design Provides a Reliable Experimental Glaucoma Mouse Model

This paper develops a biologically inspired microbead platform for inducing chronic ocular hypertension in mice, leading to retinal ganglion cell loss and visual pathway impairment.

Loss of ZNRF3/RNF43 Unleashes EGFR in Cancer

The paper shows that ZNRF3/RNF43 ubiquitinates and degrades EGFR, and their loss increases EGFR signaling, promoting cancer growth.

Fish Blood Response to Ash-Induced Environmental Alkalinization, and their Implications to Wildfire-Scarred Watersheds

This study shows that ash from wildfires increases water pH, causing rapid physiological stress in Chinook salmon, with greater effects at higher temperatures.

AlphaFold2 structures template ligand discovery

This study evaluates AlphaFold2 models for ligand discovery, finding they perform similarly to experimental structures despite conformational differences, and identify potent agonists for the 5-HT2A receptor.

CK-666 and CK-869 differentially inhibit Arp2/3 iso-complexes

This study shows CK-666 and CK-869 differentially inhibit Arp2/3 iso-complexes, with CK-869 uniquely affecting ArpC1B and Arp3-containing complexes, impacting phagocytosis and migration in macrophages.

Positive selection analyses identify a single WWE domain residue that shapes ZAP into a super restriction factor

This study identifies a single residue in ZAP's WWE domain that enhances its antiviral activity against alphaviruses by improving viral translation inhibition.

Examining models of modern human origins through the analysis of 43 fully sequenced human Y chromosomes

This study analyzes 43 fully sequenced human Y chromosomes to evaluate the Recent Out of Africa and Recent Out of East Asia models of modern human origins, finding stronger support for the latter.

Coordinated differentiation of human intestinal organoids with functional enteric neurons and vasculature

This study develops an in vitro method to generate human intestinal organoids containing multiple cell types, including neurons, endothelial cells, and smooth muscle, which functionally mimic gut physiology.

Fourth dose of Microneedle Array Patch of SARS-CoV-2 S1 Protein Subunit Vaccine Elicits Robust Long-lasting Humoral Responses in mice

This study evaluates a microneedle array patch-based S1 subunit vaccine in mice, showing that four doses induce robust, long-lasting immune responses against multiple SARS-CoV-2 variants.

Reconciling ASPP-p53 Binding Mode Discrepancies through an Ensemble Binding Framework that Bridges Crystallography and NMR Data

This study reconciles discrepancies in ASPP-p53 binding modes by showing that an ensemble of simulated complexes better aligns with experimental data than single crystal structures.

Parkinson's genes orchestrate pyroptosis through selective trafficking of mtDNA to leaky lysosomes

The paper identifies a pyroptotic pathway involving Parkinson's disease proteins and mtDNA trafficking to lysosomes.

SOD1 is a synthetic lethal target in PPM1D-mutant leukemia cells

This study identifies SOD1 as a synthetic lethal target in PPM1D-mutant leukemia cells through CRISPR/Cas9 screening, revealing a dysregulated redox landscape and potential therapeutic strategy.

The pore-forming apolipoprotein APOL7C drives phagosomal rupture and antigen cross-presentation by dendritic cells

This study identifies APOL7C as a pore-forming protein that facilitates phagosomal rupture and antigen cross-presentation by cDC1s.

Collagenesis Orchestrates Mechanoadaptive Homeostasis of Intervertebral Disc

The paper identifies a novel mechanoadaptive process in intervertebral discs through collagenesis, revealing TRPV4's role in collagen II synthesis and mechanical stress adaptation.

Unbiased phosphoproteomics analysis unveils modulation of insulin signaling by extramitotic CDK1 kinase activity in human myotubes

The paper uses phosphoproteomics to show that CDK1 activity modulates insulin signaling and glucose uptake in human myotubes, with group-specific phosphorylation changes observed.

Concerted epithelial and stromal changes during progression of Barrett's Esophagus to invasive adenocarcinoma exposed by multi-scale, multi-omics analysis

This study uses multi-omics analysis to show coordinated changes in epithelial, stromal, and immune compartments during Barrett's Esophagus progression to adenocarcinoma, revealing early appearance of cancer-associated fibroblasts and immunosuppressive microenvironment.

Chikungunya virus glycoproteins transform macrophages into productive viral dissemination vessels.

This study identifies CHIKV glycoproteins E2 and E1 as key factors that enable macrophages to support viral replication and dissemination by counteracting host restriction factors.