Deconstructing Intratumoral Heterogeneity through Multiomic and Multiscale Analysis of Serial Sections
P. G. Schupp, S. J. Shelton, D. J. Brody, R. Eliscu, B. E. Johnson, T. Mazor, K. W. Kelley, M. B. Potts, M. W. McDermott, E. J. Huang, D. A. Lim, R. O. Pieper, M. S. Berger, J. F. Costello, J. J. Phillips, M. C. Oldham
This study develops MOMA, a multiomic and multiscale analysis method to deconstruct intratumoral heterogeneity in IDH-mutant astrocytomas, revealing molecular features and spatial distributions of malignant clones.
bioRxiv · Jun 21, 2023Cancer Biology