E. J. Huang

Defining RNA oligonucleotides that reverse deleterious phase transitions of RNA-binding proteins with prion-like domains

The paper identifies short RNAs that prevent and reverse pathological fibrillization of RNA-binding proteins like FUS and TDP-43, showing therapeutic potential for ALS/FTD.

Deconstructing Intratumoral Heterogeneity through Multiomic and Multiscale Analysis of Serial Sections

This study develops MOMA, a multiomic and multiscale analysis method to deconstruct intratumoral heterogeneity in IDH-mutant astrocytomas, revealing molecular features and spatial distributions of malignant clones.

NEMO reshapes the protein aggregate interface and promotes aggrephagy by co-condensation with p62

This study identifies a NF-κB-independent role of NEMO in proteostasis by promoting aggrephagy through co-condensation with p62.

Autophagy cargo receptors are secreted via extracellular vesicles and particles in response to endolysosomal inhibition or impaired autophagosome maturation

This study identifies a secretory autophagy pathway that releases autophagy cargo receptors via extracellular vesicles when endolysosomal function is inhibited or autophagosome maturation is disrupted.

Label-retention expansion microscopy

This paper introduces label-retention expansion microscopy (LR-ExM) to prevent fluorescence signal loss and enable high-efficiency labeling, achieving molecular resolution in visualizing clathrin-coated pits.