J. F. Costello

Challenges in the discovery of tumor-specific alternative splicing-derived cell-surface antigens in glioma

The paper identifies tumor-specific alternative splicing events in glioma that could generate cell-surface antigens but finds significant spatiotemporal heterogeneity and lack of proteomic evidence.

Tumor-wide RNA splicing aberrations generate immunogenic public neoantigens

The paper identifies tumor-wide splicing aberrations that generate public neoantigens, enabling T-cell-based immunotherapies targeting intratumoral heterogeneity.

Deconstructing Intratumoral Heterogeneity through Multiomic and Multiscale Analysis of Serial Sections

This study develops MOMA, a multiomic and multiscale analysis method to deconstruct intratumoral heterogeneity in IDH-mutant astrocytomas, revealing molecular features and spatial distributions of malignant clones.

Identification of Cancer-Associated Fibroblasts in Glioblastoma and Defining Their Pro-tumoral Effects

The paper identifies cancer-associated fibroblasts in glioblastoma and shows their pro-tumoral effects through interactions with glioblastoma stem cells.

Cancer-specific loss of TERT activation sensitizes glioblastoma to DNA damage

This study shows that reducing GABPB1L in TERT-mutant glioblastomas, combined with chemotherapy, reduces tumor growth by impairing DNA damage response.

DNA methylation classification in diffuse glioma shows little spatial heterogeneity after adjusting for tumor purity

This study shows DNA methylation subtypes in diffuse gliomas are spatially consistent after adjusting for tumor purity, indicating inherent cellular heterogeneity rather than tumor-specific variation.