Computational design of a protein family that adopts two well-defined and structurally divergent de novo folds
K. Y. Wei, D. Moschidi, M. J. Bick, S. Nerli, A. C. McShan, L. P. Carter, P.-S. Huang, D. A. Fletcher, N. G. Sgourakis, S. E. Boyken, D. Baker
This paper designs a protein family with two structurally divergent folds, showing that sequences can adopt distinct conformations under different conditions.
bioRxiv · Sep 4, 2019 · PreprintBiochemistry