P.-S. Huang

Photoswitchable binders enable temporal dissection of endogenous protein function

This paper introduces photoswitchable DARPins (psDARPins) for optical control of endogenous protein function, demonstrating their use in inhibiting ERK and Ras and studying EGFR to ERK signaling.

An all-atom protein generative model

This paper introduces an all-atom diffusion model for protein structure generation that co-designs structure and sequence, producing high-quality proteins with accurate sidechain behavior.

Computational design of a protein family that adopts two well-defined and structurally divergent de novo folds

This paper designs a protein family with two structurally divergent folds, showing that sequences can adopt distinct conformations under different conditions.

Structure and Functional Binding Epitope of V-domain Ig Suppressor of T-cell Activation (VISTA)

This study determines the crystal structure of human VISTA and identifies its binding epitope for an anti-VISTA antibody and VSIG3.