Author

K. Zinovjev

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Research Focus:protein folding & dynamics· 2 Approach:statistical model· 2 Approach:experimental assay· 1 Approach:mechanistic / dynamical model· 1 Assay:protein structure· 1 Assay:structural biology· 1

Frequent Co-Authors

M. van der Kamp· 2 shared A. J. Mulholland· 1 shared A. Jäckering· 1 shared B. Strodel· 1 shared C. J. Schofield· 1 shared C. K. Colenso· 1 shared C. L. Tooke· 1 shared J. O' Loughlin· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersBiochemistry

M. van der Kamp

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3 papers

Recent·Most cited

Influence of Wobbling Tryptophan and Mutations on PET Degradation Explored by QM/MM Free Energy Calculations

A. Jäckering, M. van der Kamp, B. Strodel, K. Zinovjev

This study uses QM/MM simulations to analyze PET degradation mechanisms in PET hydrolases, revealing conformational changes and the impact of QM methods on reaction pathways.

bioRxiv · Apr 30, 2024Biochemistry

4-Thiaproline accelerates the slow folding phase of proteins containing cis prolines in the native state by two orders of magnitude

J. O' Loughlin, K. Zinovjev, S. Napolitano, M. Van der Kamp, M. Rubini

This study shows that 4-thiaproline accelerates the refolding of proteins with cis proline residues by two orders of magnitude without affecting thermodynamic stability or enzymatic activity.

bioRxiv · Jun 23, 2023 · PreprintBiochemistry

Tautomer-specific deacylation and {Omega}-loop flexibility explain carbapenem-hydrolyzing, broad-spectrum activity of the KPC-2 β-lactamase

C. L. Tooke, P. Hinchliffe, M. Beer, K. Zinovjev, C. K. Colenso, C. J. Schofield, A. J. Mulholland, J. Spencer

This study identifies how tautomer-specific deacylation and {Omega}-loop flexibility enable KPC-2 β-lactamase to efficiently hydrolyze carbapenems, revealing structural and energetic mechanisms for its broad-spectrum activity.

bioRxiv · Nov 11, 2022Biochemistry