Author

C. L. Tooke

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:protein folding & dynamics· 3 Approach:statistical model· 3 Approach:deep learning· 2 Research Focus:drug response / drug discovery· 2 Assay:structural biology· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1

Frequent Co-Authors

J. Spencer· 4 shared A. J. Mulholland· 3 shared A. S. F. Oliveira· 2 shared M. Beer· 2 shared P. Hinchliffe· 2 shared A. R. Mack· 1 shared A. T. Y. Li· 1 shared B. Balega· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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4 shared papersBiochemistry

J. Spencer

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Author profile →

4 papers

Recent·Most cited

Dynamical Responses Predict a Distal Site that Modulates Activity in an Antibiotic Resistance Enzyme

M. Beer, A. S. F. Oliveira, C. L. Tooke, P. Hinchliffe, A. T. Y. Li, B. Balega, J. Spencer, A. J. Mulholland

The paper uses dynamical simulations and experiments to identify a distal site in an antibiotic resistance enzyme that modulates activity when mutated.

bioRxiv · Apr 29, 2024Biochemistry

Harvesting and amplifying gene cassettes confers cross-resistance to critically important antibiotics

P. Dulyayangkul, T. Beavis, W. W. Lee, R. Ardagh, F. Edwards, F. Hamilton, I. Head, K. J. Heesom, O. Mounsey, M. Murarik, C. Reding, N. Satapoomin, J. M. Shaw, Y. Takebayashi, C. L. Tooke, , M. B. Avison

The paper shows that gene cassettes in an integron, amplified by IS26, confer resistance to amikacin and piperacillin/tazobactam, often leaving meropenem as the last-resort antibiotic.

bioRxiv · Dec 2, 2023 · PreprintMicrobiology

Tautomer-specific deacylation and {Omega}-loop flexibility explain carbapenem-hydrolyzing, broad-spectrum activity of the KPC-2 β-lactamase

C. L. Tooke, P. Hinchliffe, M. Beer, K. Zinovjev, C. K. Colenso, C. J. Schofield, A. J. Mulholland, J. Spencer

This study identifies how tautomer-specific deacylation and {Omega}-loop flexibility enable KPC-2 β-lactamase to efficiently hydrolyze carbapenems, revealing structural and energetic mechanisms for its broad-spectrum activity.

bioRxiv · Nov 11, 2022Biochemistry

Allosteric communication in Class A β-lactamases occurs via Cooperative Coupling of Loop Dynamics

I. Galdadas, S. Qu, A. S. F. Oliveira, E. Olehnovics, A. R. Mack, M. F. Mojica, P. K. Agarwal, C. L. Tooke, F. L. Gervasio, J. Spencer, R. A. Bonomo, A. J. Mulholland, S. Haider

This study identifies allosteric communication pathways in Class A β-lactamases using molecular dynamics simulations, showing how amino acid substitutions affect enzyme activity and antibiotic resistance.

bioRxiv · Dec 30, 2020Biophysics