Tumor subclones, where are you?
X. Su, S. Bai, G. Xie, Y. Shi, L. Zhao, G. Yang, F. Tian, K.-Y. He, L. Wang, X. Li, Q. Long, Z.-G. Han
This study compares bulk and single-cell mutational analysis to assess tumor clonal structure, finding that bulk analysis underestimates subclonal complexity and dynamic evolution.
bioRxiv · Jul 10, 2022 · PreprintCancer Biology