G. Xie

Noncaloric monosaccharides induce excessive sprouting angiogenesis in zebrafish via foxo1a-marcksl1a signal

This study shows noncaloric monosaccharides cause excessive angiogenesis in zebrafish by activating foxo1a-marcksl1a signaling, leading to ectopic tip cell formation.

Differential modulation of cellular phenotype and drug sensitivity by extracellular matrix proteins in primary and metastatic pancreatic cancer cells

This study shows that ECM proteins differentially affect morphology, proliferation, and drug sensitivity in primary but not metastatic pancreatic cancer cells, with transcriptomic changes in primary cells.

Phenotypic, genomic, and transcriptomic heterogeneity in a pancreatic cancer cell line

The paper characterizes phenotypic, genomic, and transcriptomic heterogeneity in MIA PaCa-2 pancreatic cancer cell clones, showing distinct traits and suggesting its use as a model for studying cancer heterogeneity.

Tumor subclones, where are you?

This study compares bulk and single-cell mutational analysis to assess tumor clonal structure, finding that bulk analysis underestimates subclonal complexity and dynamic evolution.

Genomic heterogeneity in pancreatic cancer organoids and its stability with culture

This study examines genomic heterogeneity and stability in pancreatic cancer organoids using single-cell whole-genome sequencing and transcriptomic analysis.

Detection of latent Epstein-Barr virus gene expression in single-cell sequencing of peripheral blood mononuclear cells

The paper detects latent EBV gene expression in single-cell RNA sequencing of peripheral blood mononuclear cells and identifies EBV-associated gene upregulation in infected B-lymphocytes.

CyTOF-Lec: Single-cell glycomics analysis reveals glycan features defining cells differentially susceptible to HIV

This study develops CyTOF-Lec to analyze glycan features in human immune cells, revealing that sialic acid levels distinguish HIV-susceptible memory CD4+ T cells.

mRNA vaccine-induced T cells respond identically to SARS-CoV-2 variants of concern but differ in longevity and homing properties depending on prior infection status

Protracted yet coordinated differentiation of long-lived SARS-CoV-2-specific CD8+ T cells during COVID-19 convalescence

The paper characterizes the long-term differentiation of SARS-CoV-2-specific CD8+ T cells in convalescent donors, showing coordinated evolution with other immune components over six months.

The repertoire of testicular extracellular vesicles cargoes and their involvement in inter-compartmental communication required for spermatogenesis

This study isolates and characterizes testicular extracellular vesicles, identifies their cargo, and shows their role in inter-compartmental communication during spermatogenesis.

First demonstration of the FLASH effect with ultrahigh dose-rate high-energy X-rays

This paper demonstrates the first use of high-energy X-rays in FLASH radiotherapy, showing effective tumor control and tissue protection in mice.

The Atlas of the In Vivo HIV CD4 T Cell Reservoir

The paper develops a method to trace latently-infected HIV CD4 T cells to their original states using CyTOF, revealing the reservoir's conserved yet tissue-specific composition and enabling isolation of unstimulated latent cells.

SARS-CoV-2-specific T cells exhibit unique features reflecting robust helper function, lack of terminal differentiation, and high proliferative potential

The paper characterizes SARS-CoV-2-specific T cells in recovered patients, finding they exhibit robust helper function, reduced terminal differentiation, and high proliferative potential.

Fructose Metabolism Contributes to the Warburg effect

This study shows cancer cells use fructose metabolism to drive the Warburg effect by converting glucose to fructose via polyol pathways and exporting fructose to the tumor microenvironment.

The landscape of mouse epididymal cells defined by the single-cell RNA-Seq

This study uses single-cell RNA sequencing to characterize mouse epididymal cell types and their gene expression profiles, identifying seven known and two novel cell populations along with region-specific gene expression signatures.

Single-cell RNA-seq reveals endoimmune cells in zebrafish

The paper identifies endoimmune cells, a novel subpopulation of endothelial cells in zebrafish, using single-cell RNA sequencing and shows their involvement in immune responses.

Transcriptome analysis of the Molecular Mechanism underlying Immunity- and Reproduction trade-off in Locusta migratoria Infected by Micrococcus luteus

This study investigates the trade-off between immunity and reproduction in locusts by analyzing transcriptome changes in response to bacterial infection.

Genetic signatures of human cytomegalovirus variants acquired by seronegative glycoprotein B vaccinees

This paper analyzes the genetic composition of HCMV variants in gB vaccinees and placebo recipients, finding reduced viral shedding and altered viral population dynamics in vaccinated individuals.