Exercise Myokine Irisin Enables Behavioral Stress Resistance in Mice
Simone M. Mellert, Joana Fernandes da Rocha, Emily S. Levy, Juliet R. Freund, Jessica B Fritz, Kaela Healy, Melanie J. Mittenbühler, Mu A, Katherine A. Blackmore, Qiuyang Zhang, Michael V. Baratta, Christiane D. Wrann, Bruce M. Spiegelman, Benjamin N. Greenwood
This study shows that increasing circulating irisin through gene delivery protects mice from stress-induced social withdrawal without exercise.
bioRxiv · Jul 20, 2026 · PreprintNeuroscience