Author

Bruce M. Spiegelman

Harvard UniversityORCID 0000-0002-7658-4802Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 1 Molecular Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Organism:Drosophila· 1 Research Focus:gene regulatory network inference· 1 Assay:proteomics· 1

Frequent Co-Authors

Melanie J. MittenbühleriD· 2 shared Abhilash JayarajiD· 1 shared Andrea ArmaniiD· 1 shared Anna M. PuszynskaiD· 1 shared Ariana Vargas‐CastilloiD· 1 shared Benjamin N. GreenwoodiD· 1 shared Birgitta A. RybackiD· 1 shared Chelsea BraithwaiteiD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersNeuroscience

Melanie J. MittenbühlerORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Exercise Myokine Irisin Enables Behavioral Stress Resistance in Mice

Simone M. Mellert, Joana Fernandes da Rocha, Emily S. Levy, Juliet R. Freund, Jessica B Fritz, Kaela Healy, Melanie J. Mittenbühler, Mu A, Katherine A. Blackmore, Qiuyang Zhang, Michael V. Baratta, Christiane D. Wrann, Bruce M. Spiegelman, Benjamin N. Greenwood

This study shows that increasing circulating irisin through gene delivery protects mice from stress-induced social withdrawal without exercise.

bioRxiv · Jul 20, 2026 · PreprintNeuroscience

Ergothioneine boosts mitochondrial respiration and exercise performance via direct activation of MPST

Hans‐Georg Sprenger, Melanie J. Mittenbühler, Yizhi Sun, Jonathan G. Van Vranken, Sebastian Schindler, Abhilash Jayaraj, Sumeet A. Khetarpal, Ariana Vargas‐Castillo, Anna M. Puszynska, Jessica B. Spinelli, Andrea Armani, Tenzin Kunchok, Birgitta A. Ryback, Hyuk‐Soo Seo, Kijun Song, , Bruce M. Spiegelman

This study identifies MPST as the direct target of EGT, showing it enhances mitochondrial respiration and exercise performance in mice.

bioRxiv · Apr 10, 2024 · PreprintMolecular Biology

Antagonistic regulation of Drosophila mitochondrial uncoupling protein UCP4b by cold and BMP signaling

Nirmalya Chatterjee, Wei Song, Phillip A. Dumesic, Bruce M. Spiegelman, Norbert Perrimon

This study identifies UCP4b as a cold-inducible gene in Drosophila that protects against cold and obesity, regulated by calcium signaling and counteracted by BMP signaling via MAD.

bioRxiv · Jan 27, 2022 · PreprintGenetics