Early disruption of entorhinal dopamine in a knock-in model of Alzheimer's disease
Tatsuki Nakagawa, Jiayun L. Xie, Marjan Savadkohighodjanaki, Yutian J. Zhang, Heechul Jun, Kai Cao, Ayana Ichii, Jason Y. Lee, Shogo Soma, Yasmeen K. Medhat, Takaomi C. Saido, Kei M. Igarashi
This study identifies early dysfunction of LEC-projecting dopamine neurons in AD mice, linking it to memory impairments and suggesting therapeutic potential through optogenetics or L-DOPA.
bioRxiv · Oct 10, 2024 · PreprintNeuroscience