Restoration of Capacity to Build Muscle Strength in Geriatric Mice by Inhibition of the Gerozyme 15-Prostaglandin Dehydrogenase
Minas Nalbandian, Ireh Kim, Elena Monti, Yutong Kelly Li, Emméran Le Moal, Peggy E. Kraft, Kaitlin Jeuris, Michelle To, L. А. Alexandrova, Jameel Barkat Lone, Zeyuan Zhang, Katrin J. Svensson, Helen M. Blau
The paper shows that inhibiting 15-PGDH in geriatric mice restores muscle strength by increasing PGE2 levels, which activates an IGF1-mediated circuit for muscle growth.
bioRxiv · Aug 7, 2026 · PreprintCell Biology