Pitfalls in performing genome-wide association studies on ratio traits
Zachary Ryan McCaw, Rounak Dey, Hari Somineni, David Amar, Sumit Mukherjee, Kaitlin P. Sandor, Theofanis Karaletsos, Daphne Koller, Hugues Aschard, George Davey Smith, Daniel G. MacArthur, Colm T. O’Dushlaine, Thomas W. Soare
This paper shows that genome-wide association studies on ratio traits can be misleading, as associations may be driven by the denominator rather than the numerator, and proposes a method to correct for collider bias.
Human Genetics and Genomics Advances · Jan 15, 2025Peer-reviewedGenetics