Impact of ligand binding on VEGFR1, VEGFR2, and NRP1 localization in human endothelial cells
Sarvenaz Sarabipour, Karina Kinghorn, Kaitlyn Quigley, Anita Kovács‐Kása, Brian Herb Annex, Victoria L. Bautch, Feilim Mac Gabhann
The paper quantifies how VEGF ligand binding affects trafficking of VEGFR1, VEGFR2, and NRP1 in human endothelial cells, showing that VEGFR2 internalization is ligand-dependent while VEGFR1 is not.
PLoS Computational Biology · Jul 16, 2025Peer-reviewedSystems Biology