Brian Herb Annex

This study shows that sFlt-1 in preeclampsia increases trophoblast leptin production via VEGFR1 and 3, leading to vascular dysfunction.

This study identifies molecular changes in perivascular adipose tissue in lupus mice, showing mitochondrial dysfunction, immune activation, and impaired adipogenic capacity.

The paper generates and validates a single-cell RNA-seq dataset to identify pathogenic endothelial metabolism in peripheral arterial disease, showing cell-type specific metabolic changes in CLTI.

The paper quantifies how VEGF ligand binding affects trafficking of VEGFR1, VEGFR2, and NRP1 in human endothelial cells, showing that VEGFR2 internalization is ligand-dependent while VEGFR1 is not.

The paper develops a computational model of endothelial cell signaling under hypoxia, showing differences in patterning pathways and the role of Notch signaling in vascular permeability.

The paper identifies a causal network controlling endothelial cell states in critical limb ischemia using transcriptomics data and cSTAR analysis.

The paper quantifies trafficking dynamics of VEGFR1, VEGFR2, and NRP1 in HUVECs, showing differences in trafficking rates and surface localization compared to non-human endothelial cells.

The paper develops a computational model to predict the role of IL-6 trans-signaling in endothelial cell signaling, showing it dominates over classic signaling in activating key pathways.