Karina Kinghorn

Mechanistic computational modeling of sFLT1 secretion dynamics

The paper develops a mechanistic model of sFLT1 secretion dynamics, showing that a delay differential equation system best fits experimental data and identifies key constrained parameters.

Impact of ligand binding on VEGFR1, VEGFR2, and NRP1 localization in human endothelial cells

The paper quantifies how VEGF ligand binding affects trafficking of VEGFR1, VEGFR2, and NRP1 in human endothelial cells, showing that VEGFR2 internalization is ligand-dependent while VEGFR1 is not.

Trafficking dynamics of VEGFR1, VEGFR2, and NRP1 in human endothelial cells

The paper quantifies trafficking dynamics of VEGFR1, VEGFR2, and NRP1 in HUVECs, showing differences in trafficking rates and surface localization compared to non-human endothelial cells.