PCIF1 loss licenses antitumour immunity via cholesterol biosynthesis
Kaixiu Li, Tianjian Lu, Zheyu Ding, Mengyao Wang, Séverine Roy, Yulan Deng, Naima Benannoune, Yuqing Wang, Elodie Edmond, Jean‐Yves Scoazec, Caroline Robert, Lunxu Liu, Shensi Shen
This study shows that PCIF1 loss enhances cholesterol biosynthesis, promoting antitumour immunity by increasing CD8+ T cell infiltration and improving response to immune checkpoint blockade.
bioRxiv · Jul 13, 2026 · PreprintCancer Biology