Shensi Shen

This study shows that PCIF1 loss enhances cholesterol biosynthesis, promoting antitumour immunity by increasing CD8+ T cell infiltration and improving response to immune checkpoint blockade.

This study identifies arginine synthesis pathway and ASS1 as key factors in mRNA translation reprogramming and ICI resistance in cutaneous melanoma, showing that targeting ASS1 can restore sensitivity to anti-PD-1.

This paper designs and characterizes RNA circuits that dynamically process signals to control gene expression in live cells.

The paper designs cooperative riboregulation in E. coli using a hierarchical toehold activation cascade and a de novo sequence design algorithm.

This study engineers a circular riboregulator in E. coli using group I PIE sequences, showing increased gene expression activation compared to linear forms.