Jean‐Yves Scoazec

This study shows that translational control of 53BP1 mRNA regulates adaptive mutability in melanoma cells, and targeting eIF4A reduces resistance to BRAF/MEK inhibitors.

This study shows that PCIF1 loss enhances cholesterol biosynthesis, promoting antitumour immunity by increasing CD8+ T cell infiltration and improving response to immune checkpoint blockade.

This study uses single-cell RNA sequencing to analyze metastatic urothelial carcinoma and identifies macrophage-driven resistance to PD-(L)1 blockade as a key mechanism.

CellsFromSpace is a reference-free tool for deconvolving and annotating spatial transcriptomic data, outperforming existing methods in accuracy and speed across multiple technologies.