DNA damage response decreases during induced pluripotent and embryonic stem cell differentiation
Kalpana Mujoo, Raj K. Pandita, Anjana Tiwari, Vijay Charaka, Sharmistha Chakraborty, Walter N. Hittelman, Nobuo Horikoshi, Clayton R. Hunt, Kum Kum Khanna, Alexander Y. Kots, E. Brian Butler, Ferid Murad, Tej K. Pandita
This study shows that DNA damage response declines during stem cell differentiation, with reduced homologous recombination repair and increased residual DNA damage.
bioRxiv · Dec 18, 2016 · PreprintCell Biology