β-Amyloid impairs Proteasome structure and function. Proteasome activation mitigates amyloid induced toxicity and cognitive deficits
Kanisa Davidson, Mehar Bano, Danitra J. Parker, Karl Rodriguez, Paweł A. Osmulski, Maria E. Gaczynska, Andrew M. Pickering
This study shows that Aβ42 oligomers impair proteasome structure and function, and that proteasome activation with TAT-DEN mitigates Aβ-induced toxicity and cognitive deficits in AD models.
bioRxiv · Oct 23, 2024 · PreprintMolecular Biology