Andrew M. Pickering

This paper develops organ-specific proteomic aging clocks in mice and shows they are more age-associated than RNA scores in some organs, suggesting post-transcriptional regulation of aging.

This study shows that Aβ42 oligomers impair proteasome structure and function, and that proteasome activation with TAT-DEN mitigates Aβ-induced toxicity and cognitive deficits in AD models.

This study shows that aging reduces proteasome function in mice brains, and enhancing proteasome activity through genetic or pharmacological means improves cognitive and neuromuscular function in aged mice.