Self-Interaction Nanoparticle Spectroscopy Predicts High-Concentration Viscosity of Therapeutic IgG1 Antibodies
Santosh Kumar Paidi, Julissa Ibrahim, К. В. Степурська, Jonathan Zarzar, Saeed Izadi, Erina Rude, Steven Luu, Daniel Kovner, Kelly O'Connor, Karenna Bol, Shrenik Mehta, Nisana Andersen, Nicole M. Stephens, Emily Makowski, Joel C. Heisler, , Tomasz Baginski
This study evaluates PS-SINS for predicting high-concentration viscosity of IgG1 antibodies, showing strong correlation with viscosity and improved model accuracy when combined with in silico data and DLS.
mAbs · Jul 30, 2026Peer-reviewedBiochemistry