Author

Jonathan Zarzar

Genentech

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Research Focus:benchmarking· 1 Approach:deep learning· 1 Approach:machine learning (classical)· 1 Assay:protein structure· 1 Approach:statistical model· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Nicole M. StephensiD· 2 shared Saeed IzadiiD· 2 shared Alavattam SreedharaiD· 1 shared Andrew M. WatkinsiD· 1 shared Bob Kelley· 1 shared Caleigh M. AzumayaiD· 1 shared Cecilia ChiuiD· 1 shared Daniel Kovner· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersBiochemistry

Nicole M. StephensORCID

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Author profile →

2 papers

Recent·Most cited

Self-Interaction Nanoparticle Spectroscopy Predicts High-Concentration Viscosity of Therapeutic IgG1 Antibodies

Santosh Kumar Paidi, Julissa Ibrahim, К. В. Степурська, Jonathan Zarzar, Saeed Izadi, Erina Rude, Steven Luu, Daniel Kovner, Kelly O'Connor, Karenna Bol, Shrenik Mehta, Nisana Andersen, Nicole M. Stephens, Emily Makowski, Joel C. Heisler, , Tomasz Baginski

This study evaluates PS-SINS for predicting high-concentration viscosity of IgG1 antibodies, showing strong correlation with viscosity and improved model accuracy when combined with in silico data and DLS.

mAbs · Jul 30, 2026Peer-reviewedBiochemistry

Rational design of oxidation-resistant antibodies through local electrostatic modulation

Sunidhi Lenka, Shrenik C. Mehta, Nicole M. Stephens, Franziska Seeger, Wei‐Ching Liang, Andrew M. Watkins, Jonathan Zarzar, Negar Jafari, M Rhyan Puno, Caleigh M. Azumaya, Ryan L. Kelly, Shuang Wu, Cecilia Chiu, Meredith Hazen, Yan Ting Wu, , Saeed Izadi

This paper develops a machine learning model to predict Trp oxidation risk in antibodies and shows that modulating electrostatic potential reduces oxidation while maintaining binding affinity.

bioRxiv · Jun 29, 2025 · PreprintBiochemistry