The circadian system is affected by Alzheimers disease independently from amyloid beta deposits
Hugo Calligaro, Brian Khov, Karina Noel, Aidan Glina, Laura van Rosmalen, Ramesh Ramasamy, Yushi Li, Michael T. Y. Lam, Hiep Dinh Le, Keun-Young Kim, Wonkyu Ju, Mark H. Ellisman, Satchidananda Panda
This study investigates circadian disruption in Alzheimer's disease using APP/PS1 mice, finding gene expression and connectomic changes in the SCN independent of amyloid beta deposits.
bioRxiv · Sep 1, 2026 · PreprintNeuroscience