Michael T. Y. Lam

This study investigates circadian disruption in Alzheimer's disease using APP/PS1 mice, finding gene expression and connectomic changes in the SCN independent of amyloid beta deposits.

This study uses EEG/EMG recordings and machine learning to analyze how time-restricted feeding affects sleep microarchitecture in mice on a high-fat diet, finding it reduces sleep fragmentation and enhances specific NREM substates.

The paper profiles the active cistrome in peripheral leukocytes of critically ill COVID-19 patients to identify severity-associated cis-regulatory elements and their regulatory programs.