Reactive Oxygen Species Generation Drives Iron Accumulation by Rotenone-Mediated Inhibition of Mitochondrial Complex I in Dopaminergic Neurons
Alaa S. Abdelrazeq Hassan, Saniya Pungliya, Matias A Murillo, Karlee Parry, Amy R Apfelbaum, Anthony S. Grillo
This study shows that rotenone inhibits mitochondrial complex I, leading to ROS generation, iron accumulation, and cytotoxicity in dopaminergic neurons.
bioRxiv · Sep 9, 2026 · PreprintBiochemistry